Amelioration of apomorphine adverse effects

Details Amelioration of apomorphine adverse effects Amelioration of apomorphine adverse effects

A - Human Necessities

61

K

A61K 31/44 (2006.01) A61K 31/473 (2006.01)

Patent

CA 2341673

Symptoms of Parkinson's disease and psychogenic male erectile dysfunction (MED) can be ameliorated through the use of apomorphine. The adverse side effects of apomorphine administration, such as nausea, vomiting, yawning, and cardiovascular effects, can be significantly reduced by a dose escalating method of acclimatization. An initial dose of apomorphine is administered to the patient, and subsequently increased over a period of time until a final apomorphine dose in excess of a desired therapeutic dose has been received by the patient. Thereafter a therapeutic dose of apomorphine, less than the final apomorphine dose, is administered to the patient with attendant reduced side effects.

Les symptômes de la maladie de Parkinson et du dysfonctionnement érectile psychogène masculin (MED) peuvent être améliorés par l'utilisation d'apomorphine. Les effets secondaires indésirables de l'administration de l'apomorphine tels que la nausée, les vomissements, les bâillements et les effets cardio-vasculaires peuvent être réduits significativement par une méthode d'acclimatation à dose progressive. Une dose initiale d'apomorphine est administrée au patient et ensuite elle est augmentée sur une durée donnée jusqu'à atteindre une dose d'apomorphine finale dépassant la dose thérapeutique voulue que reçoit le patient. Ensuite, une dose thérapeutique d'apomorphine, inférieure à la dose d'apomorphine finale, est administrée au patient avec des effets secondaires concomitants réduits.

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