Amid and urea derivatives

Details Amid and urea derivatives Amid and urea derivatives

C - Chemistry, Metallurgy

07

C

C07C 237/42 (2006.01) A61K 31/16 (2006.01) A61K 31/27 (2006.01) A61K 31/33 (2006.01) C07C 235/38 (2006.01) C07C 237/22 (2006.01) C07C 237/52 (2006.01) C07C 251/48 (2006.01) C07C 255/44 (2006.01) C07C 255/57 (2006.01) C07C 255/60 (2006.01) C07C 259/10 (2006.01) C07C 271/12 (2006.01) C07C 271/20 (2006.01) C07C 271/64 (2006.01) C07C 275/24 (2006.01) C07C 275/40 (2006.01) C07C 275/42 (2006.01) C07C 311/04 (2006.01) C07C 311/08 (2006.01) C07C 311/29 (2006.01) C07C 311/46 (2006.01) C07C 317/18 (2006.01) C07C 317/

Patent

CA 2185737

Compounds of formula (I): Image (I) wherein: R1 is alkyl; Ra, Rb, Rc and Rd are the same or different and each is hydrogen, optionally substituted alkyl or various other organic groups; R3 is alkyl; R4 is a group of formula (II), (III), (IV), (V), (VI), (VII), (VIII) or (IX): Image (II) Image (VI) Image (III) Image (VII) Image (VIII) Image (IV) Image (V) Image (IX) wherein: A1 is a single bond, alkylene or alkenylene; A is or alkenylene; A3 is a single bond, alkyleneor alkenylene; R5a and R5b are the same or different and each is hydrogen, alkyl or various other groups; R6 is alkyl or phenyl; R7 is hydrogen or alkyl; R8 is alkyl or various other groups; and n is 0 or 1] and pharmaceutically acceptable salts thereof have valuable inhibitory activity against acyl-CoA: cholesterol acyl transferase.

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