Amidation process for the preparation of cathepsin k inhibitors

C - Chemistry – Metallurgy – 07 – C

Patent

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Details

C07C 315/04 (2006.01) A61K 31/277 (2006.01) A61P 19/10 (2006.01) A61P 35/04 (2006.01) C07B 43/06 (2006.01) C07C 317/32 (2006.01)

Patent

CA 2682622

This invention describes an amidation process whereby amino acids of the Formulae IIA or IIB can be activated and treated with an amine in the presence of a base to yield amides of the Formula (I), without loss of optical purity.

Cette invention concerne un procédé d'amidation par lequel des acides aminés représentés par les formules IIA ou IIB peuvent être activés et traités à l'aide d'une amine en présence d'une base afin de produire des amides représentés par la formule (I), sans perte de pureté optique.

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