Amide and carbamate derivatives of alkyl substituted...

Details Amide and carbamate derivatives of alkyl substituted... Amide and carbamate derivatives of alkyl substituted...

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/4745 (2006.01) A61K 31/541 (2006.01) C07D 471/14 (2006.01)

Patent

CA 2622079

Amide and carbamate derivatives of N-[4-(4-amino-1H-imidazo[4,5-c]quinolin-1- yl)butyl]methanesulfonamides with an ethyl, methyl, or n-propyl substituent at the 2-position, pharmaceutical compositions containing these compounds, methods of making the compounds, and methods of use of these compounds in modulating the immune system, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.

L'invention concerne des dérivés amide et carbamate de N-[4-(4-amino-1H-imidazo[4,5-c]quinolin-1-yl)butyl]méthanesulfonamides comprenant un substituant éthyle, méthyle, ou n-propyle en position 2, des compositions pharmaceutiques comprenant ces composés, des procédés de production desdits composés, et des procédés d'utilisation de ces derniers pour moduler le système immunitaire, pour induire la biosynthèse de cytokines chez des animaux et dans le traitement de maladies, notamment de maladies virales et néoplasiques.

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