Amide and ester matrix metalloproteinase inhibitors

Details Amide and ester matrix metalloproteinase inhibitors Amide and ester matrix metalloproteinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 239/91 (2006.01) A61K 31/472 (2006.01) A61K 31/517 (2006.01) A61K 38/55 (2006.01) A61P 9/10 (2006.01) A61P 19/02 (2006.01) A61P 29/00 (2006.01) C07D 217/24 (2006.01) C07D 239/72 (2006.01) C07D 239/96 (2006.01)

Patent

CA 2513115

This invention provides compounds of Formula I or a pharmaceutically acceptable salt thereof, wherein G1, Q, D, and G2 are as defined above for Formula I. Compounds of Formula I, or a pharmaceutically acceptable salt thereof, are inhibitors of MMP-13. The compounds are useful for treating diseases mediated by MMP-13, including the diseases recited herein such as breast cancer, cartilage damage, rheumatoid arthritis, and osteoarthritis.

La présente invention concerne des composés de formule I ou un sel pharmaceutiquement acceptable de ces derniers. Dans ladite formule, G?1¿, Q, D et G?2¿ sont tels que définis dans la formule. Les composés de formule I, ou un sel pharmaceutiquement acceptable de ces derniers, sont des inhibiteurs de MMP-13. Lesdits composés sont utiles pour le traitement de maladies induites par les MMP-13, notamment les maladies énoncées ici telles que le cancer du sein, les lésions cartilagineuses, la polyarthrite rhumatoïde et l'ostéo-arthrite.

Affiliated with

Also associated with

Rating

Amide and ester matrix metalloproteinase inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Amide and ester matrix metalloproteinase inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Amide and ester matrix metalloproteinase inhibitors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1606940