Amide based glucagon superfamily peptide prodrugs

Details Amide based glucagon superfamily peptide prodrugs Amide based glucagon superfamily peptide prodrugs

C - Chemistry, Metallurgy

07

K

C07K 14/605 (2006.01) A61K 38/26 (2006.01) A61K 47/48 (2006.01) C07K 17/08 (2006.01)

Patent

CA 2747499

Prodrug formulations of glucagon superfamily peptides are provided wherein the glucagon superfamily peptide has been modified by the linkage of a dipeptide to the glucagon superfamily through an amide bond linkage. The prodrugs disclosed herein have extended half lives and are converted to the active form at physiological conditions through a non-enzymatic reaction driven by chemical instability.

L'invention porte sur des formulations comme promédicaments de peptides de la superfamille du glucagon, le peptide de la superfamille du glucagon ayant été modifié par la liaison d'un dipeptide à la superfamille du glucagon par l'intermédiaire d'une liaison amide. Les promédicaments décrits ici ont des demi-vies prolongées et sont convertis en la forme active à des conditions physiologiques par une réaction non enzymatique commandée par une instabilité chimique.

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