C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/62 (2006.01) A61K 38/28 (2006.01) A61P 3/10 (2006.01) C07K 1/107 (2006.01)
Patent
CA 2744558
Prodrug formulations of insulin and insulin analogs are provided wherein the insulin peptide has been modified by an amide bond linkage of a dipeptide prodrug element. The prodrugs disclosed herein have extended half lives of at least 10 hours, and more typically greater than 2 hours, 20 hours and less than 70 hours, and are converted to the active form at physiological conditions through a non-enzymatic reaction driven by chemical instability.
Préparations de promédicaments insuliniques et d'analogues insuliniques dans lesquels le peptide de l'insuline à été modifié par une liaison d'un élément de promédicament dipeptidique. Les promédicaments de l'invention ont des demi-vies accrues d'au moins 10 heures, plus généralement de plus de 2 heures, de 20 heures et moins de 70 heures, et sont convertis en forme active en conditions physiologiques par l'intermédiaire d'une réaction non enzymatique commandée par instabilité chimique.
Cheng Shujiang
Dimarchi Richard D.
Kou Binbin
Indiana University Research And Technology Corporation
Smart & Biggar
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