Amide compounds

Details Amide compounds Amide compounds

C - Chemistry, Metallurgy

07

D

C07D 295/14 (2006.01) A61K 31/135 (2006.01) A61K 31/16 (2006.01) A61K 31/215 (2006.01) A61K 31/41 (2006.01) A61K 31/44 (2006.01) A61K 31/495 (2006.01) C07C 237/20 (2006.01) C07C 237/44 (2006.01) C07D 211/46 (2006.01) C07D 211/62 (2006.01) C07D 213/75 (2006.01) C07D 263/58 (2006.01) C07D 271/06 (2006.01)

Patent

CA 2502764

Disclosed is an amide compound of the formula: Image wherein X is a divalent group such as O, S, or the like; M is arylene, cycloalkylene or divalent heterocyclic group; R1, R2, R3 and R4 are each hydrogen or substituent, provided that at least one of them is substituent; R5 is H, alkyl, aralkyl or amino-protecting group; m is an integer of 0-6; R6 is aryl, cycloalkyl, alkyl, alkoxy or the like; and R7 is aryl, heterocyclic group or -CO(Y)p R12 in which Y is O, S, NH or the like, p is 0 or 1 and R12 is H, alkyl, aryl, aralkyl or the like. The amide compound is useful as an intermediate for producing another amide compound having a similar structure but having R-A-X- in place of HX- in which R is heterocyclic group or the like and A is a bond or an alkylene group. The other amide compound is useful as an anti-inflammatory agent.

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