C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 417/12 (2006.01) A61K 31/427 (2006.01) A61P 31/18 (2006.01) C07D 277/82 (2006.01) C07D 417/14 (2006.01)
Patent
CA 2706155
The present invention relates to compounds that have CYP450 inhibiting properties and are therefore useful as boosters of certain drugs, i.e. they are able to increase at least one of the pharmacokinetic variables of certain drugs when co-administered. The invention further provides the use of said compounds as improvers of the bioavailability of certain drugs. Methods for the preparation of the compounds of the invention and pharmaceutical compositions are also provided.
La présente invention concerne des composés qui ont des propriétés d'inhibition du cytochrome P450 et qui sont par conséquent utiles comme renforçateurs de certains médicaments, c'est-à-dire qu'ils sont capables d'augmenter au moins une des variables pharmacocinétiques de certains médicaments lorsqu'ils sont administrés conjointement avec ceux-ci. L'invention concerne en outre l'utilisation desdits composés comme agents améliorant la biodisponibilité de certains médicaments. L'invention concerne également des procédés de préparation des composés de l'invention et de compositions pharmaceutiques.
Baumeister Judith Eva
Hache Geerwin Yvonne Paul
Hallenberger Beate Sabine
Jonckers Tim Hugo Maria
Sasaki Jennifer Chiyomi
Gowling Lafleur Henderson Llp
Tibotec Pharmaceuticals Ltd.
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