C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 241/18 (2006.01) A61K 31/495 (2006.01) A61P 35/00 (2006.01) C07D 213/30 (2006.01) C07D 213/56 (2006.01) C07D 213/75 (2006.01) C07D 215/14 (2006.01) C07D 217/14 (2006.01) C07D 217/16 (2006.01) C07D 217/22 (2006.01) C07D 231/12 (2006.01) C07D 231/38 (2006.01) C07D 237/28 (2006.01) C07D 241/12 (2006.01) C07D 249/12 (2006.01) C07D 249/14 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 405/04 (2006.01) C07D 405/12 (2006.01) C07D 413/12 (2006.01) C07D 471/04 (2006.01) C07D 48
Patent
CA 2394703
Amide compounds that modulate and/or inhibit the activity of certain protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating tyrosine kinase signal transduction in order to modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer as well as other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.
L'invention concerne des composés amides qui modulent et/ou inhibent l'activité de certaines protéines kinases. Ces composés et les compositions pharmaceutiques qui les contiennent sont capables d'induire la transduction du signal de la tyrosine kinase, de manière à moduler et/ou inhiber la prolifération cellulaire non voulue. L'invention concerne également l'utilisation thérapeutique ou prophylactique de compositions pharmaceutiques contenant de tels composés, ainsi que des procédés de traitement du cancer et d'autres pathologies associées à l'angiogenèse et/ou la prolifération cellulaire, non désirées, telles que la rétinopathie diabétique, le glaucome néovasculaire, la polyarthrite rhumatoïde et le psoriasis, ces procédés consistant à administrer des doses efficaces de tels composés.
Bender Steven Lee
Bhumralkar Dilip
Collins Michael Raymond
Cripps Stephan James
Deal Judith Gail
Agouron Pharmaceuticals Inc.
Smart & Biggar
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