Amide compounds for the potentiation of cholinergic activity

Details Amide compounds for the potentiation of cholinergic activity Amide compounds for the potentiation of cholinergic activity

C - Chemistry, Metallurgy

07

C

C07C 233/65 (2006.01) A61K 31/166 (2006.01) A61P 25/18 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2371827

The present invention relates to compounds of the formula: (See formula I) wherein R1 and R2 are taken together to form pentenylene condensed with benzene optionally substituted with C1-C6 alkyl, C1-C6 alkoxy, aryl, aryloxy or halogen, R3 is lower alkyl, lower alkoxy, Phenyl or halogen, R3 is phenyl substituted with halogen, X is CH, Y is -NH-, and Q is (See formula II) or a salt; or, R1 and R2 are taken together to form butenylene condensed with benzene, R3 is phenyl substituted with halogent X is CH, Y is -NH-, and Q is (See formula III) and the indan ring formed by taking together R1, R2 and X is substituted by -Y-Q-R3 at the 2-position, or a salt thereof. The invention further relates to pharmaceutical compositions containing the compounds or a salt thereof as well as the use of those compounds.

L'invention concerne des composés amide, utiles comme médicaments, de formule (I) dans laquelle R<1> et R<2> représentent chacun un aryle ou aralkyle inférieur ou forment, pris ensemble, un alkylène inférieur ou alcénylène inférieur, chacun pouvant être substitué par un aryle ou pouvant être condensé avec un hydrocarbure cyclique éventuellement substitué par un alkyle inférieur, alcoxy inférieur, aryle, aryloxy ou halogène, R<3> représente un alkyle inférieur, alcoxy inférieur, aryle, arylamino ou aryloxy, chacun pouvant être substitué par un alcoxy inférieur ou halogène, pyridyle ou pyridylamino, X représente CH ou N, Y représente une seule liaison ou -NH-, et Q représente la formule (1) ainsi que leur sel.

Affiliated with

Also associated with

Rating

Amide compounds for the potentiation of cholinergic activity does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Amide compounds for the potentiation of cholinergic activity, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Amide compounds for the potentiation of cholinergic activity will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1578258