Amide compounds intermediates

Details Amide compounds intermediates Amide compounds intermediates

C - Chemistry, Metallurgy

07

D

C07D 263/32 (2006.01) C07C 233/31 (2006.01)

Patent

CA 2341921

Disclosed are amide compounds of the formula: Image wherein R1" is Image (in which R4, R5, R6 and R7 are each H, halo, alkyl, alkoxy, CF3, OH or NH2 provided that at least one of them is other than H); R" is cyclohexyl or 4-fluorophenyl and R2 is alkyl or haloalkyl). They are useful as intermediates for producing oxazole compounds of the formula: Image wherein one of R and R1 is Image (in which R3 is alkyl, amino or alkylamino and the other symbols are as defined above) and the other is cycloalkyl, heterocycle or aryl and R2 is as defined above, that are cyclooxygenase-2 (COX-2) inhibitors and are as useful as pharmaceuticals.

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