Amide compounds, their production and use

Details Amide compounds, their production and use Amide compounds, their production and use

C - Chemistry, Metallurgy

07

C

167/268, 260/308

C07C 237/22 (2006.01) A61K 31/165 (2006.01)

Patent

CA 1316941

Abstract of the Disclosure Amide Compounds, Their Production and Use New amide compounds of the general formula [I]: Image [I] wherein R is a hydrogen atom or an acyl group, m is an integer of 1 to 3, n is an integer of 1 to 4, p is an integer of 1 or 2, q is an integer of 1 to 6, x is aninteger of 2 to 6 and y is an integer of 1 to 3, with the proviso that, when (i) Image , (ii) n is 1, (iii) p is 1, (iv) q is 5 and (v) R is hydrogen atom, [(CH2)x-NH]y is neither (CH2)2NH(CH2)3NH(CH2)3NH nor (CH2)2NH- (CH2)4NH(CH2)3NH, and salts thereof have excellent glutamate receptor-inhibitingactivities, and they can be produced by the following reaction scheme: Image [II] [III] or Image [IV] [V] wherein the symbols are as defined above except that the hydroxyl, imino or/and amino group or groups may be protected.

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