Amide derivative and medicine

Details Amide derivative and medicine Amide derivative and medicine

C - Chemistry, Metallurgy

07

D

C07D 213/74 (2006.01) A61K 31/496 (2006.01) A61K 31/506 (2006.01) A61P 35/02 (2006.01) A61P 43/00 (2006.01) C07D 239/42 (2006.01) C07D 401/04 (2006.01) C07D 401/14 (2006.01) C07D 403/14 (2006.01) C07D 405/14 (2006.01) C07D 417/04 (2006.01)

Patent

CA 2551529

The present invention is directed to an amide derivative having excellent BCR-ABL tyrosine kinase inhibitory activity, or a salt thereof. The present invention provides an amide derivative represented by the following general formula [1]: (see formula 1) (see formula 6) (wherein R1 represents -CH2-R11, etc.; R2 represents alkyl, halogen, haloalkyl, etc.; R3 represents hydrogen, etc.; Het1 represents a group of the formula [6] as above, etc.; and Het2 represents pyrimidinyl, etc.), or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same as an active ingredient. The compound of the present invention is useful as a BCR-ABL tyrosine kinase inhibitor.

Un dérivé d'amide ou un sel de celui-ci possède une excellente activité inhibitrice de tyrosine kinase BCR-ABL. Le dérivé d'amide est représenté par la formule générale suivante: [1] [6] dans laquelle R1 représente -CH2-R11 (R11 représente un groupe hétérocyclique azoté saturé), etc.; R2 représente alkyle, halogéno, haloalkyle, etc.; R3 représente hydrogène, etc.; Het1 représente le groupe représenté par la formule chimique [6] figurant plus haut, etc. L'invention concerne aussi une composition médicinale qui contient en tant que principe actif le dérivé d'amide ou le sel. Les composés sont utiles en tant qu'inhibiteur de tyrosine kinase BCR-ABL.

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