Amide derivatives

Details Amide derivatives Amide derivatives

C - Chemistry, Metallurgy

07

D

C07D 403/06 (2006.01) C07C 233/11 (2006.01) C07D 211/22 (2006.01) C07D 295/145 (2006.01) C07D 295/182 (2006.01) C07D 295/185 (2006.01) C07D 401/14 (2006.01) C07D 403/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01)

Patent

CA 2147155

A novel asymmetric synthesis is provided for preparing optically active amides of formula (A) and their salts. In the formula, X represents (a) or (b), R represents a mono or bicyclic aryl or heteroaryl group, R is an aryl or heteroaryl radical and R2 and R3 have specified meanings. The products are useful as 5-HT1A antagonists. Novel diesters useful as intermediates in the process are also disclosed.

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