Amide derivatives

Details Amide derivatives Amide derivatives

C - Chemistry, Metallurgy

07

K

C07K 5/078 (2006.01) A61K 31/435 (2006.01) A61K 31/505 (2006.01) A61K 31/675 (2006.01) A61K 38/05 (2006.01) C07D 471/04 (2006.01) C07F 9/547 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2136619

The present invention relates to certain novel amide derivatives which are pyrido(3,4-b)indol-2-ylacetamides of formula (I) which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase (HNE), making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treat- ment of diseases in mammals in which HLE is implicated. The invention also includes intermediates useful in the synthesis of these amide derivatives, processes for preparing the amide derivatives, pharmaceutical compositions containing such amide de- rivatives and methods for their use.

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