Amide derivatives

Details Amide derivatives Amide derivatives

A - Human Necessities

61

K

A61K 31/165 (2006.01) A61K 31/24 (2006.01) A61K 31/38 (2006.01) A61K 31/44 (2006.01) A61K 31/50 (2006.01) C07C 233/44 (2006.01) C07C 233/65 (2006.01) C07C 233/66 (2006.01) C07C 233/69 (2006.01) C07C 233/76 (2006.01) C07C 233/83 (2006.01) C07C 235/46 (2006.01) C07C 235/84 (2006.01) C07C 237/12 (2006.01) C07C 237/22 (2006.01) C07C 237/30 (2006.01) C07C 255/29 (2006.01) C07D 213/81 (2006.01) C07D 213/82 (2006.01) C07D 237/24 (2006.01) C07D 333/38 (2006.01)

Patent

CA 2308461

Compounds represented by general formula (1) or pharmaceutically acceptable salts thereof, useful as a remedy for neuroretinal degeneration, or the like, wherein Ar represents optionally substituted phenyl, etc.; n represents 0, 1 or 2; R1 represents hydrogen, optionally substituted alkyl, etc.; R2 and R3 represent each independently optionally substituted alkyl, etc.; R4 and R5 represent each independently hydrogen or optionally substituted alkyl; and R6 represents hydrogen, hydroxyl or alkyl.

L'invention a trait à des composés représentés par la formule générale (1), ou à des sels pharmaceutiquement acceptables de ceux-ci, qui sont utiles pour traiter une dégénérescence neurorétinienne ou analogue. Dans la formule, Ar représente éventuellement un phényle substitué, etc.; n représente 0, 1 ou 2; R?1¿ est hydrogène, un alkyle éventuellement substitué, etc.; R?2¿ et R?3¿ sont chacun indépendamment un alkyle éventuellement substitué, etc.; R?4¿ et R?5¿ sont chacun indépendamment hydrogène ou un alkyle éventuellement substitué; et R?6¿ est hydrogène, hydroxyle ou alkyle.

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