Amide derivatives

Details Amide derivatives Amide derivatives

C - Chemistry, Metallurgy

07

C

C07C 237/42 (2006.01) A61K 31/44 (2006.01) A61K 31/444 (2006.01) A61K 31/496 (2006.01) A61P 29/00 (2006.01) C07C 255/57 (2006.01) C07D 213/81 (2006.01) C07D 213/82 (2006.01)

Patent

CA 2361819

This invention concerns amide derivatives of Formula (I) wherein X is CH or N; Y is CH or N; m is 0-3; R1 is a group such as hydroxy, halogeno, trifluoromethyl, cyano, mercapto, nitro, amino, carboxy and carbamoyl; n is 0- 3; R2 is a group such as hydroxy, halogeno, trifluoromethyl, cyano, mercapto, nitro, amino, carboxy and (1-6C)alkoxycarbonyl; R3 is hydrogen, halogeno, (1- 6C)alkyl or (1-6C)alkoxy; q is 0-4; and Q is a group such as aryl, aryloxy, aryl-(1-6C)alkoxy, arylamino, <u>N</u>-(1-6C)alkyl-arylamino and aryl-(1- 6C)alkylamino; or pharmaceutically-acceptable salts or <u>in-vivo</u>- cleavable esters thereof; processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases or medical conditions mediated by cytokines.

Cette invention concerne des dérivés amides représentés par le formule (I). Dans cette formule X est CH ou N; Y est CH ou N; m est 0-3; R?1¿ est un groupe hydroxy, halogèno, trifluorométhyle, cyano, mercapto, nitro, amino, ou carboxy et carbamyle; n est 0-3; R?2¿ est un groupe hydroxy, halogèno, trifluorométhyle, cyano, mercapto, nitro, amino, ou carboxy et (1-6C)alcoxycarbonyle; R?3¿ est hydrogène, halogène, (1-6C)alkyle ou (1-6C)alcoxy; q est 0-4; et Q est un groupe aryle, aryloxy, aryle-(1-6C)alcoxy, arylamino ou <u>N</u>-(1-6C)alkyle-arylamino and aryle-(1-6C)alkylamino. Cette formule peut être composée de sels pharmaceutiquement acceptables ou d'esters clivables <u>in-vivo</u> de ces groupes. L'invention concerne aussi des processus de préparation de ces dérivés, des compositions pharmaceutiques les contenant et leur utilisation dans le traitement de maladies ou d'états pathologiques induits par les cytokines.

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