Amide derivatives

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 239/91 (2006.01) A61K 31/513 (2006.01)

Patent

CA 2543351

The invention concerns a compound of the Formula (I) wherein m is 0-2 and each R1 is a group such as hydroxy, halogeno, trifluoromethyl heterocyclyl and heterocyclyloxy; R2 is halogeno, trifluoromethyl or (1-6C)alkyl; R3 is hydrogen, halogeno or (1-6C)alkyl; and R4 is (3-6C)cycloalkyl;or pharmaceutically-acceptable salts thereof; processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases or medical condions mediated by cytokines.

La présente invention concerne un composé représenté par la formule (I) dans laquelle m représente 0, 1 ou 2 et chaque R?1¿ représente un groupe tel que hydroxy, halogéno, trifluorométhyle hétérocyclyle et hétérocyclyloxy; R?2¿ représente halogéno, trifluorométhyle ou alkyle (1-6C); R?3¿ représente hydrogène, halogéno ou alkyle(1-6C); et R?4¿ représente cycloalkyle(3-6C). Cette invention concerne ce composé ou ses sels pharmaceutiquement acceptables, des procédés de préparation de ces derniers, des compositions pharmaceutiques contenant ces derniers ainsi que leur utilisation dans le traitement des maladies ou des états pathologiques induits par les cytokines. Formule (I)

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