C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 213/81 (2006.01) A61K 31/41 (2006.01) A61K 31/435 (2006.01) A61P 9/00 (2006.01) A61P 25/00 (2006.01) A61P 29/00 (2006.01) A61P 37/00 (2006.01) C07D 213/89 (2006.01) C07D 215/50 (2006.01) C07D 233/90 (2006.01) C07D 237/24 (2006.01) C07D 261/18 (2006.01) C07D 401/12 (2006.01) C07D 413/12 (2006.01) C07D 513/04 (2006.01)
Patent
CA 2644369
Compounds of Formula (I) wherein R1 is aryl, cyclohexyl or heterocyclyl, or (C1-4)alkyl substituted by aryl, cyclohexyl or heterocyclyl, R2 is defined heterocyclyl, R3 is alkyl, aryl, cyclohexyl or heterocyclyl, or (C1-4)alkyl substituted by aryl, cyclohexyl or heterocyclyl, R4 is H or alkyl, or R3 and R4 together with the carbon atom to which they are attached are cycloalkyl fused with aryl, and their use as pharmaceuticals.
L'invention concerne des composés de formule (I), dans laquelle R1 représente un aryle, un cyclohexyle ou un hétérocyclyle ou un (C1-4)alkyle substitué par un aryle, un cyclohexyle ou un hétérocyclyle, R2 représente un hétérocyclyle, R3 représente un alkyle, un aryle, un cyclohexyle ou un hétérocyclyle ou un (C1-4)alkyle substitué par un aryle, un cyclohexyle ou un hétérocyclyle, R4 représente H ou un alkyle, ou bien R3 et R4 forment ensemble avec l'atome de carbone auquel ils sont attachés un cycloalkyle condensé avec un aryle. L'invention concerne également leur utilisation en tant que produits pharmaceutiques.
Arista Luca
Hoegenauer Klemens
Jaksche Herbert
Schmiedeberg Niko
Werner Gudrun
Fetherstonhaugh & Co.
Novartis Ag
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