Amide derivatives and their therapeutic use

Details Amide derivatives and their therapeutic use Amide derivatives and their therapeutic use

C - Chemistry, Metallurgy

07

C

C07C 233/11 (2006.01) A61K 31/16 (2006.01) C07C 17/14 (2006.01) C07C 45/46 (2006.01) C07C 57/58 (2006.01) C07C 57/60 (2006.01) C07C 57/62 (2006.01) C07C 57/76 (2006.01) C07C 59/56 (2006.01) C07C 69/65 (2006.01) C07C 69/732 (2006.01) C07C 235/34 (2006.01)

Patent

CA 2190009

A compound of formula (I), wherein R1 and R2 are independently selected from chloro, fluoro, bromo, C1-6 alkyl, C1-6 alkoxy or C1-6 haloalkyl provided that both R1 and R2 are not fluoro; R3 and R4 are independently selected from hydrogen and C1-6 alkyl, and pharmaceutically acceptable salts, solvates or physiologically functional derivatives thereof, their use in medicine, particularly the phrophylaxis or treatment of conditions associated with inflammation, arthritis, or pain, pharmaceutical compositions comprising them, and processes for their preparation are disclosed.

Composé de la formule (I) ainsi que ses sels, solvates ou dérivés physiologiquement fonctionnels, acceptables sur le plan pharmacologique. Dans cette formule R?1¿ et R?2¿ sont choisis indépendamment parmi chloro, fluoro, bromo, alcoyle C¿1-6?, alcoxy C¿1-6? ou haloalcoyle C¿1-6? à la condition que R?1¿ et R?2¿ ne soient pas tous deux fluoro; R?3¿ et R?4¿ sont choisis indépendamment parmi hydrogène et alcoyle C¿1-6?. L'invention concerne l'utilisation de ces composés en médecine, notamment dans la prophylaxie ou le traitement d'états associés à l'inflammation, à l'arthrite ou à la douleur. L'invention concerne également des compositions pharmaceutiques contenant ces composés ainsi que des procédés de préparation de ceux-ci.

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