C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 237/22 (2006.01) A61K 31/16 (2006.01) C07D 241/02 (2006.01)
Patent
CA 2573378
The present invention relates to ketone derivatives that are inhibitors of histone deacetylase (HDAC). The compounds of the present invention are useful for treating cellular proliferative diseases, including cancer. Further, the compounds of the present invention are useful for treating neurodegenerative diseases, schizophrenia and stroke among other diseases.
La présente invention concerne des dérivés cétoniques inhibiteurs de l'histone déacétylase (HDAC). Les composés de l'invention conviennent au traitement d'affections cellulaire proliférantes y-compris le cancer. En outre, les composés de la présente invention conviennent au traitement d'affections neurodégénératives, de la schizophrénie et des accidents cérébro-vasculaires.
Chakravarty Prasun K.
Colletti Steven L.
Ingenito Raffaele
Jones Philip
Meinke Peter T.
Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.p.a.
Merck & Co. Inc.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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