Amide derivatives as inhibitors of histone deacetylase

C - Chemistry – Metallurgy – 07 – D

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C07D 209/18 (2006.01) A61K 31/405 (2006.01) A61P 35/00 (2006.01) C07D 401/12 (2006.01) C07D 409/12 (2006.01)

Patent

CA 2573380

The present invention relates to carboxylic acid derivatives that are inhibitors of histone deacetylase (HDAC). The compounds of the present invention are useful for treating cellular proliferative diseases, including cancer. Further, the compounds of the present invention are useful for treating neurodegenerative diseases, schizophrenia and stroke among other diseases.

La présente invention concerne des dérivés d'acide carboxylique qui sont des inhibiteurs d'histone déacétylase (HDAC). Les composés de cette invention conviennent pour le traitement des maladies prolifératives cellulaires, dont le cancer. Ces composés conviennent également bien pour le traitement de diverses autres maladies, telles que les pathologies neurodégénératives, la schizophrénie ou les accidents vasculaires cérébraux.

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