Amide derivatives as selective neuropeptide y receptor...

C - Chemistry – Metallurgy – 07 – C

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C07C 237/04 (2006.01) A61K 31/16 (2006.01) A61K 31/275 (2006.01) A61K 31/33 (2006.01) A61K 31/40 (2006.01) A61K 31/41 (2006.01) A61K 31/445 (2006.01) A61K 31/454 (2006.01) A61K 31/495 (2006.01) C07C 235/02 (2006.01) C07C 255/25 (2006.01) C07C 255/30 (2006.01) C07C 323/52 (2006.01) C07D 207/04 (2006.01) C07D 207/16 (2006.01) C07D 207/337 (2006.01) C07D 209/20 (2006.01) C07D 209/52 (2006.01) C07D 211/18 (2006.01) C07D 211/44 (2006.01) C07D 211/60 (2006.01) C07D 211/66 (2006.01) C07D 211/70 (2006.01) C07D 213/

Patent

CA 2251368

Amide derivatives having formula (I) or pharmaceutically acceptable salts thereof wherein R1-R5 are each individually selected from the group of substituents including hydrogen, halogen, hydroxyl, thiol, lower alkyl, substituted lower alkyl, alkenyl, alkynyl, alkylalkenyl, alkylalkynyl, alkoxy, alkylthio, acyl, aryloxy, amino, amido, carboxyl, aryl, substituted aryl, heterocyle, heteroaryl, substituted heterocycle, heteroalkyl, cycloalkyl, substituted cycloalkyl, alkylcycloalkyl, alkylcycloheteroalkyl, nitro, and cyano exhibit selective neuropeptide Y receptor antagonistic activity.

La présente invention concerne des dérivés amides représentés par la formule générale (I) ou certains de leurs sels pharmaceutiquement admis. Dans cette formule générale, R¿1?-R¿5? appartiennent chacun individuellement au groupe des substituants constitué par hydrogène, halogène, hydroxyle, thiol, alkyle inférieur, alkyle inférieur substitué, alcényle, alcynyle, alkylalcényle, alkylalcynyle, alcoxy, alkylthio, acyle, aryloxy, amino, amido, carboxyle, aryle, aryle substitué, hétérocycle, hétéroaryle, hétérocycle substitué, hétéroalkyle, cycloalkyle, cycloalkyle substitué, alkylcycloalkyle, alkylcyclohétéroalkyle, nitro et cyano. Ces dérivés amides font preuve d'une bonne activité comme antagonistes sélectifs du récepteur du neuropeptide Y.

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