Amide derivatives for the treatment of diseases mediated by...

A - Human Necessities – 61 – K

Patent

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A61K 31/165 (2006.01) A61K 31/167 (2006.01) A61K 31/196 (2006.01) A61K 31/277 (2006.01) A61K 31/495 (2006.01) A61K 31/5375 (2006.01) A61K 31/5377 (2006.01) A61K 31/54 (2006.01) C07C 235/56 (2006.01) C07C 235/84 (2006.01) C07C 237/40 (2006.01) C07C 237/42 (2006.01) C07C 255/57 (2006.01) C07D 295/155 (2006.01) C07D 295/185 (2006.01)

Patent

CA 2300051

The invention concerns the use of amide derivatives of formula (I) wherein: R1 and R2 are substituents such as hydroxy, C1-6alkoxy, mercapto, C1-6alkylthio, amino, C1-6alkylamino and di-(C1-6alkyl)amino; m and p are independently 0-3; R3 is C1-4alkyl; q is 0-4; and R4 is aryl or cycloalkyl; or a pharmaceutically acceptable salt thereof in the manufacture of a medicament for use in the treatment of diseases or medical conditions mediated by cytokines.

L'invention concerne l'utilisation de dérivés amide de formule (I) dans laquelle R?1¿ et R?2¿ représentent des substituants par exemple hydroxy, alcoxy en C¿1-6?, mercapto, alkylthio en C¿1-6?, amino, alkylamino en C¿1-6? et di-(alkyl C¿1-6?)amino; m et p, pris indépendamment, ont une valeur comprise entre 0 et 3; R?3¿ représente alkyle en C¿1-4?; q a une valeur comprise entre 0 et 4; et R?4¿ représente aryle ou cycloalkyle; ou un sel pharmaceutiquement acceptable de ces derniers. On utilise ces dérivés pour préparer un médicament qui est utilisé dans le traitement de maladies ou des états pathologiques induit(e)s par les cytokines.

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