Amide derivatives of antibiotic a 40926

Details Amide derivatives of antibiotic a 40926 Amide derivatives of antibiotic a 40926

C - Chemistry, Metallurgy

07

K

C07K 9/00 (2006.01) A61K 38/14 (2006.01) C07K 1/00 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2109601

The present invention is directed to novel antibiotic A 40926 derivatives characterized by having a carboxy, (C1-C4)alkoxy- carbonyl, aminocarbonyl, (C1-C4)alkylaminocarbonyl, di(C1- C4)alkylaminocarbonyl or hydroxymethyl substituent on the N-acylaminoglucuronyl moiety and a hydroxy or a polyamine substituent in position 63 of the molecule. The compounds of the invention show high in vitro activity against glycopeptide resistant Enterococci and Staphylococci.

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