Amide derivatives of hyaluronic acid in osteoarthrosis

A - Human Necessities – 61 – K

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A61K 31/728 (2006.01) A61P 19/02 (2006.01)

Patent

CA 2598331

The present invention concerns amide derivatives of hyaluronic acid (HA) and biomaterials made of amide derivatives of hyaluronic acid (HA) , particularly the hexadecylamide of HA, administered by the intraarticular route as a partial/total substitute for synovial fluid to treat joints affected by osteoarthrosis (OA) as well as cases of joint inflammation and/or trauma that cause damage to the cartilage and/or synovia (associated with pain) . Lastly, we describe and claim their use in the treatment of joints where the entire structure shows signs of wear due to physiological aging.

L'invention concerne des dérivés d'amide d'acide hyaluronique (HA) et des biomatériaux constitués de dévirés d'amide d'acide hyaluronique (HA), en particulier de l'hexadécylamide de HA, administré par voie intra-articulaire, en tant que substitut partiel/total de fluide synovial pour traiter des articulations atteintes d'ostéoarthrose (OA) ainsi que des cas d'inflammations articulaires et/ou de traumatismes provoquant des lésions aux cartilages et à la synovie (associées à de la douleur). L'invention concerne également l'utilisation de ces dérivés pour traiter des articulations dans lesquelles toute la structure montre des signes d'usure dus au vieillissement physiologique.

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