Amide derivatives, their production and use

Details Amide derivatives, their production and use Amide derivatives, their production and use

C - Chemistry, Metallurgy

07

D

C07D 317/70 (2006.01) A61K 31/165 (2006.01) A61K 31/166 (2006.01) A61K 31/36 (2006.01) A61K 31/47 (2006.01) A61K 31/4709 (2006.01) A61K 31/4741 (2006.01) A61K 31/496 (2006.01) A61K 31/5377 (2006.01) C07C 235/66 (2006.01) C07D 215/48 (2006.01) C07D 317/60 (2006.01) C07D 401/04 (2006.01) C07D 405/04 (2006.01) C07D 491/04 (2006.01)

Patent

CA 2285402

The present invention provides a compound represented by formula (1) wherein R1 is an amino group which may be substituted; R2 is a hydrogen atom or a lower alkyl group which may be substituted; X is a methyne group which may be substituted or N(O)m (m is 0 or 1); a ring A is a homo- or hetero-cycle which is substituted by a halogen atom, lower alkyl, lower alkoxy or lower alkylenedioxy; and a ring B is a homo- or hetero-cycle which may be substituted; or a salt thereof, which exhibits excellent cell differentiation- inducing action and cell differentiation-inducing factor action-enhancing action, and is useful in the treatment and prevention of various nerve diseases of bone/joint diseases.

L'invention concerne un composé représenté par la formule (1), dans laquelle R?1¿ est un groupe amino éventuellement substitué; R?2¿ est un atome d'hydrogène ou un groupe alkyle inférieur éventuellement substitué; X est un groupe méthényle éventuellement substitué ou N(O)m (m étant 0 ou 1); le noyau A est un homocycle ou un hétérocycle substitué par un atome d'halogène, alkyle inférieur, alcoxy inférieur ou alkylènedioxy inférieur; et le noyau B et un homocycle ou un hétérocycle éventuellement substitué; ou un sel dudit composé. Le composé et son sel sont très actifs pour induire la différenciation cellulaire et stimuler l'activité des facteurs induisant la différenciation, et sont utiles pour traiter et prévenir diverses maladies nerveuses et osseuses/articulaires.

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