Amide-imide derivatives of low molecular weight homopolymers...

Details Amide-imide derivatives of low molecular weight homopolymers... Amide-imide derivatives of low molecular weight homopolymers...

C - Chemistry, Metallurgy

07

D

260/306.3

C07D 207/404 (2006.01) A61K 31/74 (2006.01) A61K 31/765 (2006.01) C08G 73/14 (2006.01)

Patent

CA 1181405

ABSTRACT The disclosure relates to pharmaceutically acceptable amide-imide derivatives of low molecular weight homopolymers of itaconic anhydride having antitumor activity, and a process of preparing such products. The derivatives are low molecular weight homopolymers of itaconic anhydride having average molecular weights of from about 400 to about 5000 and derivatized to contain (a) half-amide, half-carboxyl acid groups and (b) imide groups in which said imide groups comprise from about 3% by weight to about 35% by weight of said derivatized groups, and the pharmaceutically acceptable cationic salt derivatives of said derivatized homopolymers.

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