Amide linked modulators of .gamma.-secretase

Details Amide linked modulators of .gamma.-secretase Amide linked modulators of .gamma.-secretase

C - Chemistry, Metallurgy

07

C

C07C 233/81 (2006.01) A61K 31/167 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2702835

The present invention relates to compounds of Formula I as shown below, wherein the definitions of A, R1 R2, R3, R4, R5, R6, R7, and R8 are provided in the specification. Com-pounds of Formula I are useful for the treatment of diseases asso-ciated with y-secretase activity, including Alzheimer's disease.

La présente invention concerne des composés de formule I tels que représentés ci-dessous, les définitions de A, de R1, de dR2, de R3, R4, de R5, de R6, de R7, et de R8 étant explicitées dans la spécification. Les composés de formule I sont utiles dans le traitement de maladies associées à l'activité de la ?-secrétase, y compris la maladie d'Alzheimer.

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