Amide substituted imidazoquinolines

Details Amide substituted imidazoquinolines Amide substituted imidazoquinolines

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61K 31/4745 (2006.01) A61P 31/12 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2376304

Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain amide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.

Cette invention concerne des composés à base d'imidazoquinoline et de tétrahydroimidazoquinoline qui possèdent une fonctionnalité amide à la position 1 et qui conviennent bien comme modificateurs de la réponse immunitaire. Les composés et les compositions selon l'invention peuvent induire la biosynthèse de diverses cytokines et sont utiles pour le traitement de diverses pathologies, dont des affections virales et des maladies néoplasiques.

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