C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/10 (2006.01) A61K 31/4439 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2674436
The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts, stereoisomers or tautomers thereof which are inhibitors of poly (ADP-ribose) polymerase (PARP) and thus useful for the treatment of cancer, inflammatory diseases, reperfusion injuries, ischemic conditions, stroke, renal failure, cardiovascular diseases, vascular diseases other than cardiovascular diseases, diabetes, neurodegenerat ive diseases, retroviral infection, retinal damage or skin senescence and UV- induced skin damage, and as chemo- and/or radiosensitizers for cancer treatment.
L'invention concerne des composés représentés par la formule (I) et des sels pharmaceutiquement acceptables, des stéréoisomères ou des tautomères de ceux-ci utilisés comme inhibiteurs de la poly (ADP-ribose) polymérase (PARP), et donc utiles pour traiter le cancer, les maladies inflammatoires, les lésions de reperfusion, les états ischémiques, les attaques, les insuffisances rénales, les maladies cardio-vasculaires, les maladies vasculaires autres que les maladies cardio-vasculaires, le diabète, les maladies neurodégénératives, les infections rétrovirales, les lésions rétiniennes ou la sénescence de la peau, et les lésions cutanées induites par les U.V.; et comme chimiosensibilisateurs et/ou radiosensibilisateurs pour traiter le cancer.
Jones Philip
Ontoria Ontoria Jesus Maria
Scarpelli Rita
Schultz-Fademrecht Carsten
Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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