Amide-type carboxamide derivatives

Details Amide-type carboxamide derivatives Amide-type carboxamide derivatives

C - Chemistry, Metallurgy

07

C

C07C 237/42 (2006.01) A61K 31/381 (2006.01) A61K 31/4025 (2006.01) A61K 31/4155 (2006.01) A61K 31/422 (2006.01) A61K 31/44 (2006.01) A61K 31/5375 (2006.01) A61P 7/02 (2006.01) A61P 43/00 (2006.01) C07D 213/75 (2006.01) C07D 213/81 (2006.01) C07D 265/32 (2006.01) C07D 333/40 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/14 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2538072

The present invention provides an amide-type carboxamide derivative of the formula [1]: (see formula 1) wherein X is a group of the formula: -N= or the formula: -CH=; R1 is a halogen atom, a lower alkyl group, and the like; R2 is a group of the formula: (see formula II) and the like; Y1 and Y2 are the same or different and each is a group selected from a halogen atom, a lower alkyl group, a lower alkoxy group, and the like; Ring A is phenyl group, and the like, or a pharmaceutically acceptable salt thereof. The derivatives of the present invention are useful as inhibitors of FXa.

L'invention concerne un dérivé carboxamide du type amide représenté par la formule (1) dans laquelle X représente N= ou CH=; R<1> représente, entre autres, halogéno, alkyle inférieur; R<2> représente par exemple (2), (Y<1> et Y<2> étant identiques ou différents et chacun représentant halogéno ou un groupe choisi parmi, entre autres, alkyles inférieurs, alcoxys inférieurs; et le cycle A représente, entre autres, phényle) ou un sel acceptable au plan pharmacologique dudit dérivé. Le dérivé et le sel de l'invention sont utiles en médecine, notamment en tant qu'inhibiteur du FXa.

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