Amides

Details Amides Amides

C - Chemistry, Metallurgy

07

K

C07K 9/00 (2006.01) A61K 38/14 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2258906

The present invention is directed to amides of antibiotic A82846B (also known as chloroorienticin A), and of N4-derivatives of A82846B. The present amide compounds are useful as antibacterials, especially for the control of gram positive bacteria; the compounds are particularly useful for the control of resistant bacterial strains, such as vancomycin-resistant-enterococci ("VRE").

L'invention concerne des amides de l'antibiotique A82846B (connu également sous le nom de chloroorienticine A) et de dérivés N?4¿ de A82846B. Ces composés d'amides sont utiles en tant qu'antibactériens servant en particulier à lutter contre les bactéries à Gram positif, ainsi que contre les souches bactériennes résistantes, telles que les enterococci résistants à la vancomycine (VRE).

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