Amides and ester of 2-¬n-(morpholinoalkyl)...

Details Amides and ester of 2-¬n-(morpholinoalkyl)... Amides and ester of 2-¬n-(morpholinoalkyl)...

C - Chemistry, Metallurgy

07

D

260/247.1

C07D 295/14 (2006.01) C07D 295/13 (2006.01)

Patent

CA 1265139

TITLE OF THE INVENTION AMIDES AND ESTER OF 2-[N-(MORPHOLINOALKYL) AMINOSULFONYL]-6-NITROBENZOIC ACIDS, USEFUL AS ADJUNCTS TO RADIATION THERAPY ABSTRACT OF THE DISCLOSURE Amide and ester derivatives of 2-[N-(morpholinoalkyl)aminosulfonyl] 6-nitrobenzoic acids are disclosed to have activity in increasing the sensitivity of hypoxic tumor cells to therapeutic radiation. Also disclosed are methods of preparing such compounds and pharmaceutical compositions including such compounds.

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