Amidine and isothiourea derivatives as inhibitors of nitric...

Details Amidine and isothiourea derivatives as inhibitors of nitric... Amidine and isothiourea derivatives as inhibitors of nitric...

C - Chemistry, Metallurgy

07

D

C07D 409/12 (2006.01) A61K 31/47 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) A61K 31/55 (2006.01) C07D 217/02 (2006.01) C07D 223/16 (2006.01) C07D 243/14 (2006.01) C07D 267/14 (2006.01) C07D 281/10 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01) C07D 417/12 (2006.01) C07D 455/04 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01) C07D 498/04 (2006.01) C07D 513/04 (2006.01)

Patent

CA 2235301

There are provided novel compounds of formula (I), wherein X, R1, R2, R3, R4 and R5 are as defined in the specification and optical isomers and racemates thereof and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy.

L'invention, qui porte sur de nouveaux composés répondant à la formule (I) dans laquelle X, R?1¿, R?2¿, R?3¿, R?4¿, et R?5¿ sont tels que défini dans le descriptif, a également trait à leurs isomères optiques et leurs racémiques ainsi qu'à leurs sels acceptables du point de vue pharmaceutique. Cette invention concerne, de surcroît, des techniques visant à la préparation de ces composés, des compositions les contenant ainsi que leur utilisation thérapeutique.

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