Amidine compounds

Details Amidine compounds Amidine compounds

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/415 (2006.01) A61K 31/425 (2006.01) A61K 31/445 (2006.01) A61K 31/47 (2006.01) A61K 31/505 (2006.01) A61K 31/55 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01) C07D 417/06 (2006.01)

Patent

CA 2327488

Compounds represented by general formula [I] or salts thereof or prodrugs of the same [I] wherein R1, R2 and R3 are the same or different and each represents hydrogen, hydroxy, lower alkyl or aryl; and R represents formulas (a), (b) and (c) (wherein each symbol has the meaning as defined in the specification). These compounds, salts thereof or prodrugs of the same are useful as factor Xa inhibitors and anticoagulants and usable in preventing and/or treating diseases caused by blood coagulation or thrombi.

L'invention concerne des composés de la formule générale (I) ou des sels ou promédicaments desdits composés. Dans ladite formule, R?1¿, R?2¿ et R?3¿ sont identiques ou différents et représentent chacun hydrogène, hydroxy, alkyle inférieur ou aryle; et R représente les formules (a), (b) et (c) (chaque symbole étant tel que défini dans le mémorandum descriptif). Ces composés et leurs sels ou promédicaments sont utiles comme inhibiteurs du facteur Xa ou anticoagulants, et s'utilisent pour la prévention et/ou le traitement de maladies provoquées par la coagulation sanguine ou thrombose.

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