Amidine derivatives as inhibitors of nitric oxide synthase

Details Amidine derivatives as inhibitors of nitric oxide synthase Amidine derivatives as inhibitors of nitric oxide synthase

C - Chemistry, Metallurgy

07

D

C07D 413/12 (2006.01) A61K 31/55 (2006.01)

Patent

CA 2288333

There are provided novel compounds of formula (I) wherein R1 represents a 2- thienyl or 3-thienyl ring and R2 represents hydrogen or C 1 to 4 alkyl and optical isomers and racemates thereof and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are selective inhibitors of the neuronal isoform of nitric oxide synthase.

L'invention concerne de nouveaux composés de la formule (I) où R1 représente un noyau 2-thiényl ou 3-thiényl et R2 représente de l'hydrogène ou alkyle C1-4. L'invention concerne également leurs isomères optiques, racémates et sels pharmaceutiquement tolérables, des procédés de préparation correspondants, des compositions les contenant et leur utilisation en thérapie. Les composés sont des inhibiteurs sélectifs de l'isoforme neuronal de monoxyde d'azote synthase.

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