A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/155 (2006.01) A61K 31/167 (2006.01) A61K 31/18 (2006.01) A61K 31/4168 (2006.01) A61P 3/10 (2006.01) A61P 5/50 (2006.01) A61P 25/28 (2006.01) A61P 43/00 (2006.01)
Patent
CA 2552094
The present invention relates to the use of amidine compounds in the treatment of amyloid-related diseases. In particular, the invention relates to a method of treating or preventing an amyloid-related disease in a subject comprising administering to the subject a therapeutic amount of an amidine compound. Among the compounds for use according to the invention are those according to the following Formula (I), such that, when administered, amyloid fibril formation, neurodegeneration, or cellular toxicity is reduced or inhibited: Formula (I).
La présente invention a trait à l'utilisation de composés d'amidine dans le traitement de maladies associées aux amyloïdes. En particulier, l'invention a trait à un procédé de traitement ou de prévention d'une maladie associée aux amyloïdes chez un sujet comprenant l'administration au sujet d'une quantité thérapeutique d'un composé d'amidine. Parmi les composés pour une utilisation selon l'invention se trouvent ceux qui sont de formule (I), de sorte que, lors de son administration, la formation fibrillaire d'amyloïdes, la neurodégénérescence, ou la toxicité cellulaire est réduite ou inhibée.
Kong Xianqi
Migneault David
Wu Xinfu
Neurochem (international) Limited
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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