A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/155 (2006.01) A61K 31/341 (2006.01) A61K 31/343 (2006.01) A61K 31/4164 (2006.01) A61K 31/4184 (2006.01)
Patent
CA 2455497
The present invention relates to the use of amidine compounds in the treatment of amyloid-related diseases. In particular, the invention relates to a method of treating or preventing an amyloid-related disease in a subject comprising administering to the subject a therapeutic amount of an amidine compound. Among the compounds for use according to the invention are those according to the following Formula (X), such that, when administered, amyloid fibril formation, neurodegeneration, or cellular toxicity is reduced or inhibited.
L'invention concerne l'utilisation de composés d'amidine pour le traitement de maladies liées à une substance amyloïde. Plus précisément, l'invention concerne une méthode de traitement ou de prévention d'une maladie liée à une substance amyloïde chez un sujet. Cette méthode consiste à administrer au sujet une quantité thérapeutique d'un composé d'amidine. On peut citer parmi les composés à utiliser selon l'invention, les composés de formule (X), permettant, lorsqu'ils sont administrés, de réduire ou d'inhiber la formation de fibrilles amyloïdes, de neurodégénérescence ou de toxicité cellulaire.
Chalifour Robert J.
Kong Xianqi
Lu Wenshuo
Wu Xinfu
Neurochem (international) Limited
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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