Amidine derivatives of 2-substituted 4- phenylimidazole

Details Amidine derivatives of 2-substituted 4- phenylimidazole Amidine derivatives of 2-substituted 4- phenylimidazole

C - Chemistry, Metallurgy

07

D

167/231, 167/237

C07D 233/64 (2006.01) C07D 233/54 (2006.01) C07D 233/68 (2006.01) C07D 233/70 (2006.01) C07D 233/84 (2006.01) C07D 233/88 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01)

Patent

CA 1257274

ABSTRACT The present invention relates to new pharmacolog- ically active amidine derivatives of 2-substituted 4-phenylimidazole of general formula I Image (I) (in which R represents a linear or branched alkyl group, a hydroxy group, a C1-3 alkoxy group, a mercapto group, a C1-3 alkylthio group, a halogen atom, a C1-3 alkylsulfinyl or alkylsulfonyl group, a sulfamoyl group, an amino group which may be substituted by one or two alkyl groups having 1 to 3 carbon atoms, an acylamino group or a phenyl group; R1 and R2, which may be the same or different, each represents a hydrogen atom or an alkyl group; R3 represents a linear or branched alkyl group optionally containing one heteroatom such as an oxygen, sulphur or nitrogen atom, an alkenyl group, an alkynyl group, a cyano group, an optionally substituted aryl or aralkyl group, a cycloalkyl or cycloaliphatic alkyl group, a substituted heterocyclic group or an alkyl group substituted by a substituted or unsubstituted heterocyclic group; R4 represents a hydrogen atom, a C1-3 alkyl or alkoxy group, a halogen atom or a cyano or carbamyl group), tautomeric forms thereof and acid addition salts of the aforementioned compounds. Processes for the preparation of the compounds of formula I and their intermediates as well as the pharmaceutical compositions containing them are also objects of this invention. The new compounds are H2-receptor blocking agents which inhibit gastric acid secretion and are useful antiulcer agents.

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