C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 9/6561 (2006.01) A61K 31/675 (2006.01) C07F 9/645 (2006.01) C07F 9/6512 (2006.01)
Patent
CA 2066224
-20- Summary Compounds of the formula I Image I, in which R can be hydrogen or C1-C4-alkyl, R1 hydrogen, C1-C6-alkyl, aryl, aryl-C1-C4-alkyl, amino-C1-C6- alkyl, C1-C6-alkylamino-C1-C4-alkyl, C1-C6-dialkyl- amino-Cl-C4-alkyl, Cl-C4-alkoxy-Cl-C4--alkyl ,~ Cl-C4- alkylthio-C1-C4-alkyl, C3-C7-alkenyl, R2 R1 or C2-C7-alkenyl, C1-C6-alkylmercapto, C1-C6 alkoxy, phenoxy-C1-C4-alkyl,amino, C1-C4-alkylamino, di- C1-C4-alkylamino, morpholino, thiomorpholino, pyrrolidino, piperidino, hexamethyleneimino, pyrazolino, imidazolino, n 0, 1 or 2 and R1 and R2, together with the carbon and the nitrogen atom to which they are attached, can form a heterocyclic five-, six- or seven-membered ring with 1 - 4 heteroatoms, whereby the heteroatoms can be the same or different and signify oxygen, nitrogen. or sulphur and the annelated ring can possibly be substituted by one or more C1-C6-alkyl, C1-C6-alkoxy, C1-C6-alkylmercapto groups, hydroxyl, amino, nitro, halogen or halomethyl, as well as their pharmacologically acceptable salts, processes for their preparation, as well as medi- caments which contain these compounds for the treatment of calcium metabolism disturbances.
Bosies Elmar
Zilch Harald
Boehringer Mannheim Gmbh
Swabey Ogilvy Renault
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