Amidines, processes for their manufacture, pharmaceutical...

Details Amidines, processes for their manufacture, pharmaceutical... Amidines, processes for their manufacture, pharmaceutical...

C - Chemistry, Metallurgy

07

D

260/242.01, 260/

C07D 487/04 (2006.01) C07D 209/18 (2006.01) C07D 471/04 (2006.01)

Patent

CA 1161433

4-12736/+ Novel amidines, processes for their manufacture, pharma- ceutical preparations containing them, and their use Abstract Novel amidines, especially N,N'-bridged carboxylic acid amidine of the general formula Image (I), in which R1 represents an aromatic radical, R2 represent optionally esterified or amidated l-carboxy-lower alkyl, Ph represents optionally substituted 1,2-phenylene and alk represents an aliphatic hydrocarbon radical separating the imino group from the methine group by from 1 to 3 carbon atoms, and their salts, have, inter alia, anti- inflammatory activity and can be used as active medica- ment substances in pharmaceutical preparations. They are produced according to methods known per se.

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