Amidino-camptothecin derivatives

Details Amidino-camptothecin derivatives Amidino-camptothecin derivatives

C - Chemistry, Metallurgy

07

D

C07D 491/22 (2006.01) A61K 31/47 (2006.01) A61K 31/4745 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2266891

A water soluble camptothecin derivative which is 20(S)-7-ethyl-9-(N-methyl-N- phenyl)amidino-camptothecin (I) and pharmaceutically acceptable salts thereof, pharmaceutical compositions containing them and a process for their preparation are described. The compound of the invention and its pharmaceutically acceptable salts are useful antitumor agents and are further characterised by having a remarkable therapeutic index.

L'invention concerne un dérivé de camptothécine hydrosoluble correspondant à 20(S)-7-éthyl-9(N-méthyl-N-phényl)amidino-camptothécine, ainsi que ses sels pharmaceutiquement acceptables, des compositions pharmaceutiques les renfermant et un de leurs procédés de préparation. Le composé de l'invention et ses sels pharmaceutiquement acceptables constituent des agents antitumoraux utiles et se caractérisent aussi par un index thérapeutique remarquable.

Affiliated with

Also associated with

Rating

Amidino-camptothecin derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Amidino-camptothecin derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Amidino-camptothecin derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1384816