C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 257/14 (2006.01) A61K 31/195 (2006.01) A61K 31/33 (2006.01) C07C 323/58 (2006.01) C07D 207/09 (2006.01) C07D 207/323 (2006.01) C07D 211/34 (2006.01) C07D 213/58 (2006.01) C07D 233/64 (2006.01) C07D 263/32 (2006.01) C07D 277/30 (2006.01) C07D 307/54 (2006.01)
Patent
CA 2126327
Amidino derivatives of formula (1) and salts, and pharmaceutically acceptable esters and amides thereof, in which: R1 is a C1-6 straight or branched chain alkyl group; a C2-6alkenyl group, a C2-6 alkynyl group, a C3-6cycloalkyl group or a C3-6cycloalkylC1-6alkyl group; Q is an alkylene, alkenylene or alkynylene group having 3 to 6 carbon atoms and which may optionally be substituted by one or more C1-3alkyl groups; a group of formula - (CH2)p X(CH2)q- where p is 2 or 3, q is 1 or 2 and X is S(O)x where x is 0; 1 or 2, O or NR2 where R2 is H or C1-6alkyl; or a group of formula-(CH2)r A(CH2)s where r is 0, 1 or 2, s is 0, 1 or 2 and A is a 3 to 6 membered carbocyclic or heterocyclic ring which may optionally be substituted, by one or more suitable substituents such as C1-6alkyl, C1-6alkoxy, hydroxy, halo, nitro, cyano; trifluoroC1-6alkyl, amino, C1-6alkylamino or diC1-6alkylamino and pharmaceutical formulations containing them are described for use in medicine, novel compounds of formula (I) and the preparation of such novel compounds are also disclosed.
Beams Richard Mansfield
Hodson Harold Francis
Palmer Richard Michael John
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
The Wellcome Foundation Limited
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