Amidino derivatives and their use as nitric oxide synthase...

C - Chemistry – Metallurgy – 07 – C

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C07C 257/14 (2006.01) A61K 31/195 (2006.01) A61K 31/33 (2006.01) C07C 323/58 (2006.01) C07D 207/09 (2006.01) C07D 207/323 (2006.01) C07D 211/34 (2006.01) C07D 213/58 (2006.01) C07D 233/64 (2006.01) C07D 263/32 (2006.01) C07D 277/30 (2006.01) C07D 307/54 (2006.01)

Patent

CA 2126327

Amidino derivatives of formula (1) and salts, and pharmaceutically acceptable esters and amides thereof, in which: R1 is a C1-6 straight or branched chain alkyl group; a C2-6alkenyl group, a C2-6 alkynyl group, a C3-6cycloalkyl group or a C3-6cycloalkylC1-6alkyl group; Q is an alkylene, alkenylene or alkynylene group having 3 to 6 carbon atoms and which may optionally be substituted by one or more C1-3alkyl groups; a group of formula - (CH2)p X(CH2)q- where p is 2 or 3, q is 1 or 2 and X is S(O)x where x is 0; 1 or 2, O or NR2 where R2 is H or C1-6alkyl; or a group of formula-(CH2)r A(CH2)s where r is 0, 1 or 2, s is 0, 1 or 2 and A is a 3 to 6 membered carbocyclic or heterocyclic ring which may optionally be substituted, by one or more suitable substituents such as C1-6alkyl, C1-6alkoxy, hydroxy, halo, nitro, cyano; trifluoroC1-6alkyl, amino, C1-6alkylamino or diC1-6alkylamino and pharmaceutical formulations containing them are described for use in medicine, novel compounds of formula (I) and the preparation of such novel compounds are also disclosed.

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