Amidinohydrazones as protease inhibitors

Details Amidinohydrazones as protease inhibitors Amidinohydrazones as protease inhibitors

C - Chemistry, Metallurgy

07

C

C07C 309/72 (2006.01) A61K 31/00 (2006.01) A61K 31/155 (2006.01) A61K 31/21 (2006.01) A61K 31/33 (2006.01) C07C 45/29 (2006.01) C07C 45/71 (2006.01) C07C 47/277 (2006.01) C07C 281/18 (2006.01) C07C 309/73 (2006.01) C07C 309/74 (2006.01) C07C 309/75 (2006.01) C07C 309/77 (2006.01) C07C 311/21 (2006.01) C07C 311/29 (2006.01) C07C 311/44 (2006.01) C07D 213/71 (2006.01) C07D 215/36 (2006.01) C07D 217/02 (2006.01) C07D 217/22 (2006.01) C07D 231/18 (2006.01) C07D 233/52 (2006.01) C07D 263/54 (2006.01) C07D 285/14

Patent

CA 2250426

Amidino and benzamidino compounds, including compounds of formula (I), wherein R1-R4, R6-R9, Y, Z, n and m are set forth in the specification, as well as hydrates, solvates or pharmaceutically acceptable salts thereof, that inhibit proteolytic enzymes such as thrombin are described. Also described are methods for preparing the compounds of formula (I).

Cette invention concerne des composés amidino et benzamidino, et notamment des composés correspondant à la formule (I) où R<1>-R<4>, R<6>-R<9>, Y, Z, n et m sont tels que définis dans la description. Cette invention concerne également des hydrates, des solvates ou des sels de ces composés acceptables sur le plan pharmaceutique, lesquels permettent d'inhiber des enzymes protéolytiques telles que la thrombine. Cette invention concerne également des procédés de préparation des composés correspondant à la formule (I).

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