Amidinoindoles, amidinoazoles, and analogs thereof as...

Details Amidinoindoles, amidinoazoles, and analogs thereof as... Amidinoindoles, amidinoazoles, and analogs thereof as...

C - Chemistry, Metallurgy

07

D

C07D 209/18 (2006.01) A61K 31/33 (2006.01) A61K 31/34 (2006.01) A61K 31/38 (2006.01) A61K 31/40 (2006.01) A61K 31/415 (2006.01) A61K 31/435 (2006.01) A61K 31/44 (2006.01) A61K 31/495 (2006.01) C07D 209/08 (2006.01) C07D 209/14 (2006.01) C07D 231/56 (2006.01) C07D 235/06 (2006.01) C07D 307/79 (2006.01) C07D 307/81 (2006.01) C07D 333/54 (2006.01) C07D 333/58 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/00 (2006.01) C07D 403/12 (2006.01) C07D 405/00 (2006.01) C07D 409/00

Patent

CA 2259573

The present application describes amidinoindoles, amidinoazoles, and analogs thereof of formula (I): wherein W, W1, W2, and W3 are selected from CH and N, provided that one of W1 and W2 is C(C(=NH)NH2) and at most two of W, W1, W2, and W3 are N and one of Ja and Jb is substituted by -(CH2)n-Z-A-B, which are useful as inhibitors of factor Xa or thrombin.

La présente demande concerne des amidinoindoles, des amidinoazoles et leurs analogues répondant à la formule (I), où W, W?1¿, W?2¿ et W?3¿ sont choisis parmi CH et N, à condition que l'un des éléments W?1¿ et W?2¿ soit C(C(=NH)NH¿2?), que deux au plus des éléments W, W?1¿, W?2¿ et W?3¿ soient N, et que l'un des éléments J?a¿ et J?b¿ soit substitué par -(CH¿2?)¿n?-Z-A-B, et pouvant être utiles en tant qu'inhibiteurs du facteur Xa ou de la thrombine.

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