Amidite derivatives and oligonucleotide derivatives

Details Amidite derivatives and oligonucleotide derivatives Amidite derivatives and oligonucleotide derivatives

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01) A61K 31/70 (2006.01) C07H 15/04 (2006.01)

Patent

CA 2216844

Compounds represented by general formula (I) (wherein X represents a group represented by general formula (II) or (III); Y represents a leaving group; and Z represents an oligonucleotide etc.). These compounds can specifically transfer oligonucleotides into cells that specifically recognize specified sugar structures and hence can be used as antiviral and antitumor agents.

Cette invention concerne des composés de formule (I) (dans laquelle X représente un groupe de formule (II) ou (III); Y représente un groupe labile; et Z représente un oligonucléotide etc.). Ces composés peuvent spécifiquement transférer des oligonucléotides dans des cellules qui reconnaissent spécifiquement des structures sucre spécifiées et par conséquent on peut les utiliser en tant qu'agents antiviraux et antitumoraux.

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