Amido compounds and their use as pharmaceuticals

Details Amido compounds and their use as pharmaceuticals Amido compounds and their use as pharmaceuticals

C - Chemistry, Metallurgy

07

D

C07D 491/107 (2006.01) A61K 31/395 (2006.01) C07D 209/62 (2006.01) C07D 211/06 (2006.01) C07D 221/20 (2006.01) C07D 241/04 (2006.01) C07D 491/20 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2571258

The present invention relates to inhibitors of 11-~ hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with expression or activity of 11-~ hydroxyl steroid dehydrogenase type 1 and/or diseases associated with aldosterone excess.

La présente invention porte sur des inhibiteurs de la déshydrogénase de type 1 stéroïde hydroxyle 11-ß, sur des antagonistes du récepteur minéralocorticoïde (MR) et sur leurs compositions pharmaceutiques. Les composés de l'invention peuvent être utiles dans le traitement de diverses maladies associées à l'expression ou à l'activité de la déshydrogénase de type 1 stéroïde hydroxyle 11-ß et/ou de maladies associées à l'excès d'aldostérone.

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