Amido compounds and their use as pharmaceuticals

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/44 (2006.01) A61K 31/445 (2006.01) A61K 31/47 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01) C07D 403/14 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2575561

The present invention relates to inhibitors of 11-.beta. hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with expression or activity of 11-.beta. hydroxyl steroid dehydrogenase type 1 and/or diseases associated with aldosterone excess.

L'invention concerne des inhibiteurs de la 11-ß-hydroxyle-stéroïde déshydrogénase de type 1, des antagonistes des récepteurs minéralocorticoïdes (MR) et des compositions pharmaceutiques de ces derniers. Les composés de l'invention peuvent être utilisés dans le traitement de diverses maladies associées à l'expression ou à l'activité de la 11-ß-hydroxyle-stéroïde déshydrogénase de type 1 et/ou de maladies associées à l'excès d'aldostérone.

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